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AKTIVITAS ANTIDIARE FRAKSI ETANOL DAUN MELINJO (GNETUM GNEMON L. (LINN.)) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI BAKTERI SALMONELLA TYPHI

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Penilaian

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One of the plants that can be used to treat diarrhea is melinjo (Gnetum gnemon L. (Linn.)). Tannin compounds in melinjo leaves which are astringent are thought to have antidiarrheal effects. This study aimed to evaluate the antidiarrheal activity of the ethanol fraction of melinjo leaves. This study used male white rats of wistar strain induced by S.typhi bacteria. The test animals were divided into 6 groups, namely a negative control group (1% NaCMC), a positive control group (Chloramphenicol), and 4 treatment groups at doses of 30, 60, 90, and 120 mg/kgBW. The results of the characterization of the ethanol fraction of melinjo leaves obtained water soluble extract content of 39.33%; ethanol soluble extract content of 24,00%; water content 7.67%; drying shrinkage 8.32%; total ash content of 8.00%; acid insoluble ash content 7.51%; microbial contamination test 0 cfu/g; and test for metal contamination of Pb 0.05) and were able to reduce the number of bacterial colonies equivalent to the positive control group to zero after 12 days of treatment. The dose of 120 mg/kgBW was the most effective as antidiarrheal based on the observed parameters of antidiarrheal activity. The total tannin content contained in the ethanol fraction of melinjo leaves was 165,736 mgTAE/g fraction. The effective dose (ED50) of the ethanol fraction of melinjo leaves as an antidiarrheal was 111,724 mg/kgBW. Keywords: Melinjo leaves, antidiarrheal, ethanol fraction, Salmonella typhi

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2207003062	T76070	T760702022	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T760702022

Publisher

Inderalaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2022

Collation

xvii, 83 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.307

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Jurusan Farmasi
Obat-obatan organik

Specific Detail Info

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Statement of Responsibility

SEPTA

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