Image of OPTIMASI DAN KARAKTERISASI FITOSOM FRAKSI ETIL ASETAT EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana L.) DENGAN VARIASI KONSENTRASI PHOSPHOLIPON 90G DAN KOLESTEROL

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OPTIMASI DAN KARAKTERISASI FITOSOM FRAKSI ETIL ASETAT EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana L.) DENGAN VARIASI KONSENTRASI PHOSPHOLIPON 90G DAN KOLESTEROL

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The mangosteen rind (Garcinia mangostana L.) contains xanthone derivative compounds including alpha mangosteen which acts as an antityrosinase. A delivery system such as phytosomes can be added to increase the active substance's penetration. The study aimed to determine the optimum formula for phytosomes with variations in phospholipone 90G and cholesterol. Phytosomes were made using the thin layer hydration method with a ratio of phopholipone 90G and cholesterol concentrations (2:0,2; 1:0,4; 1:0,2; 2:0,4). The optimum formula was determined by a factorial design of 22 using Design-Expert 12® on the response of adsorption efficiency, decrease in adsorption efficiency, and decrease in pH after the stability test. The optimum formula obtained was characterized by particle size, PDI (polydispersity index), and zeta potential. The optimum formula was obtained using 2% phopholipon 90G and 0.2% cholesterol with an adsorption efficiency value of 96.895 ± 0.015, a decrease in adsorption efficiency of 0.703 ± 0.020, and a decrease in pH of 0.026 ± 0.004. The results of the characterization of the optimum formula obtained particle size of 391.6 nm, PDI 0.685, and zeta potential -13.9 mV

Availability
Inventory Code Barcode Call Number Location Status
2207004227T80430T804302022Central Library (Referens)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T804302022
Publisher
Inderalaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya.,
Collation
xviii, 105 hlm.; ilus.; 29 cm
Language
Indonesia
ISBN/ISSN
-
Classification
615.307
Content Type
-
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
Jurusan Farmasi
Obat yang berasal dari Tumbuhan
Specific Detail Info
-
Statement of Responsibility
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No other version available

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