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OPTIMASI SINTESIS NANOPARTIKEL PERAK-EKSTRAK BIJI PINANG MUDA DENGAN VARIASI KONSENTRASI PERAK NITRAT DAN EKSTRAK MENGGUNAKAN METODE SIMPLEX LATTICE DESIGN

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Penilaian

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Silver nanoparticles have been widely used because of their antibacterial activities. However, the synthesis of silver nanoparticles still uses physical and chemical methods that are not eco-friendly. Therefore, green synthesis of silver nanoparticles was carried out by utilizing the ethanol extract of unripe areca nut which is more eco-friendly. The unripe areca nut contains high levels of flavonoids and polyphenols which can be a bioreduction and stabilizer. This study aims to optimize the silver nanoparticles formula using the simplex lattice design method through the Design-Expert 12® device with various concentrations of silver nitrate (AgNO3) and extract. The study used 9 formulas to determine the maximum wavelength and absorbance values of silver nanoparticles SPR, then characterization of the resulting optimum formula were carried out. The results of the phytochemical screening of the ethanol extract of unripe areca nut contain flavonoids, alkaloids, polyphenols, tannins, and saponins which can reduce and stabilize silver nanoparticles. The flavonoid content in the extract was 110,849 mg CE/g extract. Optimum formula optimization results were obtained from the concentration of silver nitrate (AgNO3) 3 mM and 3 mL of 10% w/v extract. The results from the optimum formula characterization show the maximum wavelength of SPR in 420 nm and absorbance 1.427, the value of particle diameter is 122.53 nm; PDI 0.35; and zeta potential -19.75 mV. The results of the physical stability test showed the formation of irreversible deposits in the 1st to 6th cycles, a shift in the SPR wavelength from 426 nm with an absorbance of 1,385 to 429 nm with an absorbance of 1,246 in the 6th cycle, and a decrease in the pH value from 9,00 to 7.97 in the 6th cycle. Based on the data obtained, the optimum formula has good particle characteristics but lacks physical stability.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2207000127	T62520	T625202022	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T625202022

Publisher

Inderalaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2022

Collation

xvii, 95 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.307

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Jurusan Farmasi
Obat yang berasal dari Tumbuhan

Specific Detail Info

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Statement of Responsibility

SEPTA

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