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OPTIMASI SEDIAAN SUNSCREEN SPRAY GEL EKSTRAK ETANOL TONGKOL JAGUNG (ZEA MAYS L.) DAN ZINK OKSIDA DENGAN VARIASI BASIS HPMC-KARBOPOL940

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Penilaian

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Excessive sun exposure can cause damage to the skin due to ultraviolet (UV) radiation so that the skin needs additional protection to avoid UV radiation. Sunscreen products can reduce the transmission of UV rays to the skin. Zinc oxide is one of the active ingredients that works as a physical blocker that is widely used, but has very low solubility and stability so that it is formulated in the form of emulsions with the aim of increasing its solubility. Corncob extract has potential as an antioxidant, namely phenolic which is also in line with the value of Sun Protection Factor (SPF). This study aims to determine the physical properties and SPF value of the optimum formula of the preparation of sunscreen spray gel corncob extract. Corn cobs were extracted by maceration method and yield a yield of 15.28%. Corncob extract was tested for total phenolics and determined the SPF value so that the total phenolic value of 13 mg GAE / g sample was tested and the SPF value at a concentration of 1000 ppm was 20,351 with moderate UV protection category. Corn cob extract was formulated into a spray gel dosage form with variations on the basis of HPMC-Karbopol940. Both bases were optimized using a design expert with a 3 replication factorial design approach which resulted in 12 run formulas. The responses analyzed were adhesive dispersion, drying power, viscosity and SPF value. The test results were analyzed by DX12 to get the optimum formula. The optimum concentration of HPMC was 0.171 % and carbopol940 0.300 % with adhesive dispersion of 138.8 seconds, drying power of 153.6 seconds, viscosity of 409 cPs and SPF value of 13.095 with moderate protection category.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2207003115	T77194	T771942022	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T771942022

Publisher

Inderalaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2022

Collation

ix, 87 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.307

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Jurusan Farmasi
Obat-obatan organik

Specific Detail Info

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Statement of Responsibility

SEPTA

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