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UJI AKTIVITAS SEDIAAN SPRAY GEL EKSTRAK ETANOL KELOPAK BUNGA ROSELLA (HIBISCUS SABDARIFFA L.) TERHADAP PENYEMBUHAN LUKA TERBUKA PADA TIKUS PUTIH JANTAN GALUR SPRAGUE DAWLEY

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Penilaian

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Wounds are a form of tissue damage to the skin and wound healing can be accelerated by treating the wound. Rosella (Hibiscus sabdariffa L.) plant can be used as a wound healer which contains flavonoid compounds, tannins, and saponins. This study aims to determine the effect of variations in the concentration of ethanolic extract of rosella petals on the characterization of spray gel preparations and open wound healing in Sprague Dawley male white rats. The treatment groups used in this study were 8 treatments, including; negative, positive, placebo, pure extract groups and variations in the concentration of spray gel ethanol extract of rosella flower petals by 10% (F1), 15% (F2), 20% (F3) and 25% (F4). Extract characterization included organoleptic test, water soluble extract content, ethanol soluble extract content, metal contamination, microbial contamination, water content, total ash content and acid insoluble total ash content. Evaluation of spray gel preparations included organoleptic tests, homogeneity, pH, viscosity, adhesion, spraying patterns, pump delivery, washability and stability. Open wounds were made using a biopsy punch with a diameter of ±8 mm and a depth of ±2 mm. Wound observations were carried out on days 4, 8, 12, 16 and 20 for 20 days and the wound diameter was measured and analyzed using imageJ and SPSS applications. The results of the characterization of the ethanolic extract of rosella flower petals obtained that all tests met the standards of the Indonesian Herbal Pharmacopoeia (2017). The results of the evaluation of the spray gel of rosella flower petals ethanol extract obtained that all tests met the requirements. The fastest wound healing is influenced by variations in the concentration of ethanol extract of rosella petals where the more concentration used, the faster the wound healing process. Based on the results of the study, it can be concluded that the best formula as a wound healer is in formula 4 with a concentration of 25% and healing time for 12 days.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2207003123	T77250	T772502022	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T772502022

Publisher

Inderalaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2022

Collation

xviii, 104 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.307

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Jurusan Farmasi
Obat-obatan organik

Specific Detail Info

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Statement of Responsibility

SEPTA

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