Text

UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT DAUN SUKUN (Arthocarpus altilis [Park.] Fosberg) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI CCl4

---

Penilaian

---

One of the Indonesian plants that has the potential as an antioxidant is breadfruit (Artocarpus altilis [Park.] Fosberg). The leaves contain flavonoids which have strong antioxidant power. This study was conducted to determine the total flavonoid content of the ethyl acetate fraction of breadfruit leaves, the effect of the preparation of the ethyl acetate fraction of breadfruit leaves on MDA levels, catalase enzyme activity, macroscopic and histopathological descriptions of male white rats of Wistar strain induced by CCl4 and to determine the best dose as an antioxidant. This study used 30 rats which were divided into 6 groups, namely normal control and negative control (Na-CMC 1%), positive control (vitamin C 10 mg/kgBW), and the test group at a dose of 25 mg/kgBW, 50 mg/kgBW, and 100 mg/kgBW. The results showed that the total flavonoid content of the ethyl acetate fraction of breadfruit leaves was 29,41 mg QE/g fraction. The three doses of the ethyl acetate fraction of breadfruit leaves had an antioxidant effect and a dose of 100 mg/kgBW had the best effect because there was no significant difference with the positive control (P>0,05). The conclusion of this study is that the variation in the concentration of the ethyl acetate fraction of breadfruit leaves affects MDA levels, catalase enzyme activity, macroscopic and histopathological features in rats with a dose of 100 mg/kgBW, the ethyl acetate fraction of breadfruit leaves can reduce plasma MDA levels and increase liver catalase enzyme activity and provide good macroscopic and histopathological picture of the liver. Keywords: breadfruit leaf (Artocarpus altilis [Park.] Fosberg), total flavonoids, catalase enzyme, MDA levels, CCl4

---

Availability

Inventory Code	Barcode	Call Number	Location	Status
2207000133	T62262	T622622022	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

-

Call Number

T622622022

Publisher

Inderalaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2022

Collation

xxii, 150 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

-

Classification

615.307

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Jurusan Farmasi
Obat-obatan organik

Specific Detail Info

-

Statement of Responsibility

SEPTA

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment