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PREPARASI DAN KARAKTERISASI SOLID LIPID NANOPARTICLES ASAM USNAT DENGAN PEMBAWA KOMBINASI PHOSPHOLIPON 90G DAN CERA FLAVA

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Penilaian

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The use of usnic acid is still limited because it has low solubility, low bioavailability and lipophilic properties that make the ability of the usnic acid delivery system to penetrate the skin difficult to control. To overcome this problem, Solid Lipid Nanoparticles (SLN) were formulated which have a nanostructured lipid matrix so that they can provide more flexibility in modulating drug release. Preparation of SLN uses a combination of high-speed homogenization and ultrasonication. The SLN formula consisted of usnic acid, phospholipon 90G:cera flava (3:7), and tween 80 whose concentrations were varied to 0.3%; 0.6%, and 1%. The percentage of entrapment efficiency (%EE) becomes the parameter to determine the best formula where the %EE results in each formula are in succession 93%; 96% and 92% so that F2 with a concentration of Tween 80 0.6% became the best formula for further characterization of solubility, particle size, PI, zeta potential and stability tests. The resulting SLN particle size is 442.3 nm with a PI value of 0.282 and a zeta potential value of -15.2 mV. The stability test showed that SLN was stable in three storage conditions with release model following zero orde, activation energy 12,76 cal/mol, kinetic constant 0,11857 mg/days and shelf-life 40 days in storages condition 25oC/60%RH and in storage condition 5 oC 0,0826 mg/days in 58 days. The results of one-way ANOVA statistical analysis showed p value

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2207000845	T68431	T684312022	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T684312022

Publisher

Inderalaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2022

Collation

xvii, 57 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.107

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Jurusan Farmasi
Obat-obatan, Materi Medika

Specific Detail Info

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Statement of Responsibility

SEPTA

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