Text

UJI KEMAMPUAN SUBMIKRO PARTIKEL CHITOOLIGOSACCHARIDE DALAM MENSTIMULASI PERTUMBUHAN PROBIOTIK LACTOBACILLUS CASEI STRAIN SHIROTA

---

Penilaian

---

Chitooligosaccharide is a chitosan derived compound resulting from the deacetylation of chitin which has great potential as a natural source of prebiotics due to its indigestible nature and beneficial effects on probiotic bacteria. This study aims to determine the effect of submicroscopic Chitooligosaccharide in stimulating the growth of Lactobacillus casei strain Shirota. Chitooligosaccharide submicroparticle preparation using sodium alginate as polymer and 20 µL CaCl2 0.018 M as crosslinker using ionic gelation method. The three formulas used variations in the weight of sodium alginate as much as 1.6; 3.2 and 4.8 mg. The best formula was found in the weight of sodium alginate 4.8 mg which had a percent encapsulation efficiency of 90.72% with a particle size characteristic of 556.8 nm; PDI value is 0.540 and zeta potential is +36.1 mV. The results of the bacterial growth activity test showed that Chitooligosaccharide submicro-particles could increase the growth of Lactobacilllus casei by 6.0 x 108 CFU/mL (13%) compared to Chitooligosaccharide without encapsulation of 5.3 x 108 CFU/mL. Chitooligosaccharide submicro particle stability test using heating-cooling method for 6 cycles with the results of the percent encapsulation efficiency (%EE) of 89.97; 70.56; 53.81; 30.45; 22.98 and 16.16% showed a decrease in the percentage of encapsulation efficiency in submicroparticle preparations

---

Availability

Inventory Code	Barcode	Call Number	Location	Status
2207000135	T62124	T621242022	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

-

Call Number

T621242022

Publisher

Inderalaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2022

Collation

xviii, 97 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

-

Classification

579.307

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Bakteri
Jurusan Farmasi

Specific Detail Info

-

Statement of Responsibility

SEPTA

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment