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FORMULASI DAN KARAKTERISASI SOLID LIPID NANOPARTICLE PEMBAWA GLIBENKLAMID DENGAN MENGGUNAKAN ASAM STEARAT DAN VARIASI JUMLAH KOSURFAKTAN PEG 400

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Penilaian

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The formulation and characterization of glibenclamide into nanoparticles is a new delivery system for the use of glibenclamide drugs. The manufacture of SLN is carried out using high speed homogenization and ultrasonication methods. The solid lipid nanoparticles glibenclamide formula consisted of stearic acid as a lipid matrix, tween 80 as a surfactant, polietilena glikol 400 as a cosurfactant, polivinil alkohol as a stabilizer and variations in the amount of polietilena glikol 400 in the three formulas, respectively 5 g, 10 g and 15 g. Solubility of solid lipid nanoparticles was tested using simulated method, that is SGF, SIF and HCl. Determination of the percent encapsulation efficiency (% EE) obtained results for the three formulas, including 88,4587±0.0085 (formula 1), 93,8709±0.0148 (formula 2), and 86,8466±0.0226 (formula 3). Formula 2 was characterized for physical properties using a particle size analyzer (PSA) so that the results for formula 2 were obtained, namely average particle size 167,0±0,6342 nm, range between 166.7 nm to 167 nm, polydispersity index 0.442±0.0145, and zeta potential -34,6±1,7146 mV. The heating-cooling stability test was carried out with a cycle test for 12 days, the results obtained in formula 2 which was slightly cloudy in white, there was no phase separation, and there was a precipitate. In the mechanical stability test, phase separation occurred in each formula. The results of the solubility test showed that solid lipid nanoparticle glibenclamide was soluble in aquadest, in SGF, in SIF and in HCl 5%. The conclusion from the research that has been done shows that the SLN glibenclamide preparation can be used as a new drug delivery system.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2207002825	T76339	T763392022	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T763392022

Publisher

Inderalaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2022

Collation

xviii, 60 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.107

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Jurusan Farmasi
Obat-obatan, Materi Medika

Specific Detail Info

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Statement of Responsibility

SEPTA

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