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UJI AKTIVITAS ANTIOKSIDAN FRAKSI N-HEKSAN DAUN BELUNTAS (Pluchea indica L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI CCl4

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Penilaian

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Beluntas leaf have antioxidant activity by inhibiting lipid peroxidation thereby preventing the formation of malondialdehyde (MDA). The purpose of this study is to determine the effect on antioxidant activity of n-hexane fraction of beluntas leaves by measuring MDA levels, knowing catalase enzyme activity and macroscopic and histopathological features of CCl4-induced rat liver. The treatments were divided into 6 groups, namely normal, negative, positive control group, treatment I with a dose of 10 mg/200gBB, treatment II with a dose of 20 mg/200gBB and treatment III with a dose of 40 mg/200gBB. The average results of MDA levels in the normal, negative, positive groups, given fraction doses of 10, 20 and 40 mg/200gBB, respectively, were 0,677; 2,732; 0,821; 1,112; 0,934 and 0,855 nmol/mL. The average results of the catalase enzyme activity in the normal, negative, positive groups, given fraction doses of 10, 20 and 40 mg/200gBB respectively were 13,081; 4,621; 21,448; 8,6288; 16,751 and 22,200 U/mL. The macroscopic and histopathological results of the liver showed an improvement after being given n-hexane fraction of beluntas leaves at doses of 10, 20 and 40 mg/200gBB when compared to the negative group. The results showed that the ethanolic extract of beluntas leaves significantly could be efficacious as an antioxidant by reducing MDA levels and increasing catalase enzyme activity (p

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2207002968	T76710	T767102022	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T767102022

Publisher

Inderalaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2022

Collation

xx, 150 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

619.907

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Jurusan Farmasi
Kedokteran Eksperimental pada Mamalia dan Manusia

Specific Detail Info

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Statement of Responsibility

SEPTA

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