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PREPARASI DAN KARAKTERISASI NANOCARRIER KITOSAN-ALGINAT PEMBAWA ASAM USNAT DENGAN VARIASI KONSENTRASI CaCl2 MENGGUNAKAN METODE GELASI IONIK

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Penilaian

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The potential utilization of usnic acid is still very limited due to its low solubility in water causes low bioavailability, so that its therapeutic effectiveness also decreases. Chitosan-Alginate polymer based nanocarrier formulation uses ionic gelation method as a new delivery system, so that it would facilitate the absorption process and increase the effectiveness of the usnic acid to achieve the target of treatment. This research aims to obtain the best nanocarrier formula that has good characterization. This research characterizes usnic acid isolate. The study used 3 formulas with various concentration of CaCl2 20 µL, 40 µL, and 100 µL. The optimum formula will be determined based on the highest %EE value and also carried out particle characterization and stability test. The result of the characterization of usnic acid isolate obtained wavelengths of 287 nm in water medium and 230 nm in methanol medium, melting point 204,3-204,8oC, and TLC with Rf 0,42. The first, second, and third formulas had %EE respectively of 95,89%; 96,43%; 98,49%. The characterization results showed the particle size value of 246,3 nm; PDI 0,412; and zeta potential +26,93 mV. Stability test showed that usnic acid nanocarrier in three storage conditions with release model following zero orde, activation energy 6,28 cal/mol, kinetic constant 0,083 mg/days with shelf-life 59 days at temperature 25oC and estimated shelf-life 71 days at temperature 5oC. The results of one-way ANOVA statistical analysis showed a significant effect of CaCl2 variation on the entrapment efficiency and usnic acid nanocarrier increased solubility compared to pure usnic acid (p

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2207000843	T68478	T684782022	Central Library (Referens)	Available but not for loan - Repaired

Detail Information

Series Title

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Call Number

T684782022

Publisher

Inderalaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2022

Collation

xvii, 95 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.020 7

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Jurusan Farmasi
Topik-topik Khusus tentang Penyakit

Specific Detail Info

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Statement of Responsibility

SEPTA

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