Image of PENGARUH DURASI ISKEMIA-REPERFUSI PADA ACUTE KIDNEY INJURY (AKI) TERHADAP GAMBARAN SELULER TUBULOINTERSTISIAL RENALIS, KADAR CYSTATIN C DAN GLOMERULAR FILTRATIONRATE (GFR) PADA TIKUS WISTAR

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PENGARUH DURASI ISKEMIA-REPERFUSI PADA ACUTE KIDNEY INJURY (AKI) TERHADAP GAMBARAN SELULER TUBULOINTERSTISIAL RENALIS, KADAR CYSTATIN C DAN GLOMERULAR FILTRATIONRATE (GFR) PADA TIKUS WISTAR

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Background: Acute Kidney Injury (AKI) is rapid decline in renal function. Most causes of AKI are ischemia/reperfusion which triggers an inflammatory response and causes renal injury. lnflammation is a prolective response and tissue repair, but it can cause fibrosis, which is the normal tissue replaced by an extracellular matrix such as collagen. Damage that occurs in the tubulointerstitial part has a large effect on renal function. Renal function can be measured by GFR using cystatin C. Kidney function can be measured by GFR using cystatin C. The purpose of this study was to determine the effect of ischemia-reperfusion duration in AKI on tubulointerstitial cellular appearance, cystatin C levels and GFR in Wistar rats and find out the correlation between tubulointerstitial cellular appearance, cystatin C levels and GFR in Wistar Rats. Method: This research is an experimental research using posttest only with a control group design. The object of research is 30 Wistar rats, the study was conducted in animal house and biomolecular laboratory of the Faculty ofMedicine, Sriwijaya University. Tubulointerstitial cellular appearance, cystatin C levels and GFR were assessed by percentage of collagen area fraction, ELISA and Larsson formula. Result: The duration of 30 minutes ischemia and reperfusion 14 days 99.1% affected the percentage of the collagen area fraction, the duration of 120 minutes ischemia and 14 days reperfusion 98.8% influenced the levels of cystatin C and 99.5% influenced GFR. There was a significant correlation between the percentage of collagen area fraction and cystatin C levels (p = 0,0001, r = 0,901), percentage of collagen and GFR area fractions (p = 0,0001, r = -0,834), and cystatin C levels and GFR (p = 0,0001, r = -915). Conclusion: There is effect between the duration of ischemia/reperfusion tubulointerstitial cellular appearance, cystatin C levels and GFR in Wistar rats and there is correlation between tubulointerstitial cellular appearance, cystatin C levels and GFR in Wistar rats.

Availability
Inventory Code Barcode Call Number Location Status
1907001747T93754T937542019Central Library (REFERENCES)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T937542019
Publisher
Inderalaya : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya.,
Collation
xvii, 158 hlm.; ill.; tab.; 28 cm.
Language
Indonesia
ISBN/ISSN
-
Classification
616.610 7
Content Type
Text
Media Type
unmediated
Carrier Type
unspecified
Edition
-
Subject(s)
Prodi Pendidikan Dokter
Penyakit pada Ginjal--glomerulonephritis
Specific Detail Info
-
Statement of Responsibility
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No other version available

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