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FORMULASI DAN KARAKTERISASI SOLID LIPID NANOPARTICLE PEMBAWA ERITROMISIN DENGAN KOSURFAKTAN PEG 400 DAN VARIASI JUMLAH ASAM STEARAT

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ERYTHROMYCIN IS A DRUG THAT HAS LOW SOLUBILITY IN WATER. THE LOW SOLUBILITY OF THE DRUG CAUSES SLOW ABSORPTION OF THE DRUG IN THE BODY AND RESULTS IN INADEQUATE BIOAVAILABILITY, SO A SOLID LIPID NANOPARTICLE OF ERYTHROMYCIN WAS CARRIED OUT TO INCREASE ITS SOLUBILITY. FORMULA SOLID LIPID NANOPARTICLE CONSISTED OF STEARIC ACID WITH VARIOUS CONCENTRATIONS AS A LIPID MATRIX, TWEEN 80 AS A SURFACTANT, PEG 400 AS A COSURFACTANT, AND PVA AS A STABILIZER. THE STUDY USED 3 FORMULAS TO TAKE THE BEST FORMULA BASED ON %EE AND THEN CARRIED OUT PARTICLE CHARACTERIZATION, PHYSICAL STABILITY TESTING, AND SOLUBILITY TESTING. THE PERCENTAGE OF EE PRODUCED BY FORMULA 1, FORMULA 2, AND FORMULA 3 IS 77.9216 ± 0.2094; 82.755 ± 0.0408; AND 81.255 ± 0.1870. THE RESULTS OF THE BEST FORMULA CHARACTERIZATION, NAMELY FORMULA 2, OBTAINED A PARTICLE SIZE OF 342.8 ± 0.3 NM, PDI 0.215 ± 0.0015; AND ZETA POTENTIAL -18.45 ± 0.15 MV. THE RESULTS OF THE PHYSICAL STABILITY TEST USING THE HEATING COOLING FOR 12 DAYS SHOWED THE RESULTS IN THE FORM OF A WHITE, SLIGHTLY CLOUDY PREPARATION, THE PH DECREASED AND INDICATED THE OCCURRENCE OF PHASE SEPARATION, AS WELL AS PHASE SEPARATION IN THE MECHANICAL STABILITY TEST. THE RESULTS OF THE SOLUBILITY TEST SHOWED THAT THE SOLID LIPID NANOPARTICLE ERYTHROMYCIN WAS COMPLETELY SOLUBLE IN AQUADEST, 5% HCL, SGF AND SIF. BASED ON THE RESULTS OF THE STUDY SHOWED THAT THE SOLUBILITY OF ERYTHROMYCIN CAN BE INCREASED BY BEING FORMULATED INTO SOLID LIPID NANOPARTICLES.

Availability
Inventory Code Barcode Call Number Location Status
2207002951T76987T769872022Central Library (Referens)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T769872022
Publisher
Inderalaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya.,
Collation
xvi, 79 hlm.; ilus.; 29 cm
Language
Indonesia
ISBN/ISSN
-
Classification
615.07
Content Type
-
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
Jurusan Farmasi
Farmakologi dan Terapi Farmakologi
Specific Detail Info
-
Statement of Responsibility
Other version/related

No other version available

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