The Sriwijaya University Library

  • Home
  • Information
  • News
  • Help
  • Librarian
  • Login
  • Member Area
  • Select Language :
    Arabic Bengali Brazilian Portuguese English Espanol German Indonesian Japanese Malay Persian Russian Thai Turkish Urdu

Search by :

ALL Author Subject ISBN/ISSN Advanced Search

Last search:

{{tmpObj[k].text}}
Image of IDENTIFIKASI POLIMORFISME GEN mTOR rs2536 DAN rs2295080 SERTA EKSPRESI ER, PR, HER-2, Ki-67 PADA PENDERITA KANKER PAYUDARA

Skripsi

IDENTIFIKASI POLIMORFISME GEN mTOR rs2536 DAN rs2295080 SERTA EKSPRESI ER, PR, HER-2, Ki-67 PADA PENDERITA KANKER PAYUDARA

Haq, Anisah Nida'ul - Personal Name;

Penilaian

0,0

dari 5
Penilaian anda saat ini :  

Introduction: Dreast cancer is a type of cancer that occurs due io neoplastic transformation of epithelial cells in the breast. This neoplastic transformation is resulted from the accumulation of genetic and epigenetic aberrations. Breast cancer is the most common cancer in the world. One of the genetic factors associated with breast cancer is mTOR gene polymorphism which mostly occurs in 3’ untranslated region and promoter region. mTOR gene polymorphism leads t o constitutional activation of mTOR translation which will initiate signalling network t o nucleus t o increase cell proliferation and differentiation. The aim of this study w as to identify the rs 2536 and rs 2295080 mTOR gene polymorphism with ER, PR, HER-2 and Ki-67 expression protein in breast cancer patients at Mohammad Hoesin General Hospital Palembang. Methods: This study was a descriptive observational study with PCR-RFLP technique using EcoRI and Fokl enzyme on thirty three patients with breast cancer. Results: rs 2536 gene polymorphism in mutant genotype (CC) found in 27 patiens (81,8%). The C allele frequency was 89,4% and the T was 10.6%. The most common genotype found in rs 2295080 gene polymorphism is wild type (TT) fo und in 19 patients (57,6%). The T allele frequency was 63,6% and the G was 36,4%. The data from Anatomical Pathology showed a tendency to increase the expression of Ki-67, ER, PR and HER-2 in rs 2536 and rs 2295080 gene polymorphism. Conclucion: rs 2536 mTOR gene polymorphism (CC) in breast cancer is more common than r s 2295080 gene polymorphism (GG).


Availability
Inventory Code Barcode Call Number Location Status
1907001602T88773T887732019Central Library (REFERENCES)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T887732019
Publisher
Inderalaya : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2019
Collation
xv, 86 hlm.; ill.; tab.; 28 cm.
Language
Indonesia
ISBN/ISSN
-
Classification
616.910 7
Content Type
Text
Media Type
unmediated
Carrier Type
unspecified
Edition
-
Subject(s)
Kanker payudara
Prodi Pendidikan Dokter
Specific Detail Info
-
Statement of Responsibility
Furika
Other version/related

No other version available

File Attachment
  • IDENTIFIKASI POLIMORFISME GEN mTOR rs2536 DAN rs2295080 SERTA EKSPRESI ER, PR, HER-2, Ki-67 PADA PENDERITA KANKER PAYUDARA
Comments

You must be logged in to post a comment

The Sriwijaya University Library
  • Information
  • Services
  • Librarian
  • Member Area

About Us

As a complete Library Management System, SLiMS (Senayan Library Management System) has many features that will help libraries and librarians to do their job easily and quickly. Follow this link to show some features provided by SLiMS.

Search

start it by typing one or more keywords for title, author or subject

Keep SLiMS Alive Want to Contribute?

© 2025 — Senayan Developer Community

Powered by SLiMS
Select the topic you are interested in
  • Computer Science, Information & General Works
  • Philosophy & Psychology
  • Religion
  • Social Sciences
  • Language
  • Pure Science
  • Applied Sciences
  • Art & Recreation
  • Literature
  • History & Geography
Icons made by Freepik from www.flaticon.com
Advanced Search