Skripsi

IDENTIFIKASI MUTASI Ala437Gly GEN Dihydropteroate Synthase (DHPS) SEBAGAI MARKER RESISTENSI plasmodium falcifarum TERHADAP SULFADOKSIN DI SUMATERA SELATAN

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Penilaian

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Plasmodium falciparum causes of severe malaria or cerebral malaria and main cause of the death in malaria case. Malaria still as a health problem in tropic and subtropic countries and also in Indonesia. Malaria caused by Plasmodium falciparum is many appeared in endemic region in Indonesia. In most of region still use Chloroquine as a first line and the combination Sulfadoxine-Pyrimetamine as a second line. Resistance case of P. falciparum to Clhoroquin and Sulfadoxine-Pyrimetamine have been reported in the world included Indonesia. In Africa, Chloroquine use widely cause the resistance fastly and also Sulfadoxine-Pyrimetamine. Main mechanism ofresistance P. falciparum to antimalaria drug is gene mutation. Mutation ofpfcrt and pfmdr gene related to P. falciparum resistance to Chloroquine. Mutation of dhps gene related to P. falciparum resitance to Sulfadoxine and dhfr gene mutation related to P. falciparum resistance to Pyrimetamin. Pfcrt and pfmdr gene mutations are more often appeared than dhps and dhfr gene mutations. The aim of research is identification A437G dhps gene mutation that related to P. falciparum resistance to Sulfadoxine in Sumatera Selatan. the result of research shows that wild-type (normal) genotype A437G dhps gene was 100% (30 from 30 isolate). Mutation A437G of dhps gene related to Sulfadoxine resistance of malaria patient infected by P. falciparum in South Sumtatera during MarchSeptember is not occurred yet. Key words: Plasmodiumfalciparum, Sulfadoxine, Resistance, A437G dhps gene

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Availability

Inventory Code	Barcode	Call Number	Location	Status
1407003698	T80803	T808032013	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T808032013

Publisher

Palembang : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2013

Collation

x, 53 hlm.: Ilus., tab.; 28 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.930 7

Content Type

Text

Media Type

unmediated

Carrier Type

unspecified

Edition

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Subject(s)

Malaria
Pendidikan Dokter
Sulfadoksin

Specific Detail Info

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Statement of Responsibility

HALIM

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