Skripsi

IDENTIFIKASI POLIMORFISME +331G/A GEN RESEPTOR PROGESTERON PADA PENDERITA ENDOMETRIOSIS DI RSUP DR. MOHAMMAD HOESIN PALEMBANG

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Penilaian

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Introduction: Endometriosis is a benign gynecologic disorder often occurring in reproductive-age women marked by the presence of endometrial glands and stromal cells outside the uterine cavity. The etiology of endometriosis remains unclear until now, but genetic factors possibly contribute in the pathogenesis of endometriosis. One of the genetic factors thought to be influencing the occurrence of endometriosis is the +331 G/A progesterone receptor gene polymorphism. This polymorphism causes an increase in the synthesis of PR-B receptor isoform, therefore reducing the PR-A/PR-B isoform ratio and increasing endometriosis risk This study aims to identify +331 G/A progesterone receptor gene polymorphism in endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang. Method: This study is an observational descriptive study on 48 endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang. Identification of +331 G/A progesterone receptor gene polymorphism was performed through polymerase chain reaction and restriction fragment length polymorphism (PCRRFLP) using NlalV restriction enzyme. Results: The GG (wild type) genotype was identified in 19 patients (39,6%) and the G A (heterozygous mutant) genotype in 29 patients (60,4%). The allotype frequencies for the G (wild type) and A (polymorphic) allotype s were 67 (69,8%) and 29 (30,2%), respectively. Conclusion: In endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang, the genotype G A was more commonly identified and the A allotype frequency was 30,2%.

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Detail Information

Series Title

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Call Number

T824802014

Publisher

Palembang : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2014

Collation

xiii, 72 hlm.; ill.; tab.; 28 cm.

Language

Indonesia

ISBN/ISSN

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Classification

618.107

Content Type

Text

Media Type

unmediated

Carrier Type

unspecified

Edition

-

Subject(s)

Endometriosis
Pendidikan Dokter
Polimorisme

Specific Detail Info

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Statement of Responsibility

HALIM

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