Skripsi

IDENTIFIKASI POLIMORFISME GIu298Asp (G894T) EKSON 7 GEN eNOS PADA PENDERITA NEFROPATI DIABETIK POPULASI MELAYU DI SUMATERA SELATAN

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Penilaian

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Diabetic nephropathy is one of microvascular complications in type 2 diabetes mellitus which can cause chronic kidney failure. This complication has a significant correlation with Glu298Asp (G894T) polymorphism of exon 7 eNOS gene in several of global population because this type of polymorphism reduces eNOS gene activity and NOS3 production until l/2x fewer than normal, the protective factor of chronic kidney failure. Nevertheless, until now there is not a research about this fact in Melayu population, especially in South Sumatera. Because of that, the aim of this research is identifying Glu298Asp (G894T) polymorphism of exon 7 eNOS gene which is cut by enzyme Dpnll in patients with nephropathy diabetic of Melayu population in South Sumatera. This research was done in a descriptive study with cross sectional sample of 30 patients with diabetic nephropathy. Identification of Glu298Asp (G894T) polymorphism was done by using PCR and RFLP (restriction fragment length polymorphism) using enzyme Dpnll. This research found Glu298Asp (G894T) polymorphism of exon 7 eNOS gene with 0% homozygote mutant allele genotype (Asp-Asp/TT), 30%, heterozygote mutant allele (Glu-Asp/GT), and 70% wild type allele genotype'(Glu-Glu/GG) where the amount of T and G allele is 15% and 85% in patients with diabetic nephropathy of Melayu population in South Sumatera The conclusion of this research is the overview of allele G and wild-type genotype was more common in patients with diabetic nephropathy of Melayu population in South Sumatera.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
1207000207	T82238	T822382012	Central Library (REFERENCES)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T822382012

Publisher

Inderalaya : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2012

Collation

xiv, 72 hlm.; ill.; tab.; 28 cm.

Language

Indonesia

ISBN/ISSN

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Classification

616.465 981 607

Content Type

Text

Media Type

unmediated

Carrier Type

unspecified

Edition

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Subject(s)

Nefropati Diabetik
Prodi Pendidikan Dokter

Specific Detail Info

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Statement of Responsibility

Furika

Other version/related

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