Skripsi

IDENTIFIKASI POLIMORFISME PROGINS (INSERSI ALU 306-PB) GEN RESEPTOR PROGESTERON PADA PENDERITA ENDOMETRIOSIS DI RUMAH SAKIT DR. MOHAMMAD HOESIN PALEMBANG

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Penilaian

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Introduction: Endometriosis, a disease defined as the growth of endometrial tissue with glands and/or stroma outside the uterine cavity, generally occurs in reproductive-age women. Although the etiology still remain unclear, heredity and genetic mutations may contribute in the occurrence of endometriosis. One of the genetic mutations, i.e. PROGINS (306-bp Alu insertion) polymorphism. This polymorphism inhibits the activity of PR-B, therefore increasing the PR-A/PR-B and trigger endometriosis. This study is conducted to identify PROGINS (306-bp Alu insertion) progesterone receptor gene polymorphism in endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang. Method: This study is an observational descriptive study on 48 endometriosis patients in Dr. Mohammad Hoesin General Hospital Palembang. Polymerase Chain Reaction (PCR) was performed to identify. Results: Tl/Tl (wild type) genotype was identified in 43 patients (89,6%) and T1/T2 (heterozygous mutant) genotype in five patients (10.4%). Out of 48 patients, T1 (wild type) allotype frequency was 91 (94.8%) and T2 (polymorphic) allotype was five (5.2%). Conclusion: Genotype Tl/Tl (wild type) and allotype T1 (wild type) were more commonly identified in this study.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
1407000335	T81876	T818762014	Central Library (REFERENCES)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T818762014

Publisher

Inderalaya : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2014

Collation

xiii, 73 hlm.; ill.; tab.; 28 cm.

Language

Indonesia

ISBN/ISSN

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Classification

618.107

Content Type

Text

Media Type

unmediated

Carrier Type

unspecified

Edition

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Subject(s)

Endometriosis
Prodi Pendidikan Dokter

Specific Detail Info

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Statement of Responsibility

Furika

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