Image of IDENTIFIKASI POLIMORFISME-938C>A PROMOTER GEN BCL-2 PADA PENDERITA KARSINOMA OVARIUM EPITEL DI RUMAH SAKIT DR. MOHAMMAD HOESIN PALEMBANG

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IDENTIFIKASI POLIMORFISME-938C>A PROMOTER GEN BCL-2 PADA PENDERITA KARSINOMA OVARIUM EPITEL DI RUMAH SAKIT DR. MOHAMMAD HOESIN PALEMBANG

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Background: Epithelial ovarian carcinoma is a malignancy arising from ovarian epithelial cell. The cellular transformation into malignant cell is known to be influenced by Bcl-2 protein family which acts as antiapoptotic agent. The -938C>A polymorphism on the Bcl-2 gene is known to be associated with various types of carcinoma. Hence, this study was proposed to identify the -938C>A polymorphism on Bcl-2 gene of epithelial ovarian carcinoma patients at dr. Mohammad Hoesin Hospital Palembang. Methods: This study was an observational descriptive study on 40 epithelial ovarian carcinoma patients at dr. Mohammad Hoesin Hospital Palembang. Identification of the -938C>A polymorphism on Bcl-2 gene was done by PCRRFLP using Bccl enzyme. Result: Zero subject (0%) with CC genotype (wild type) was identified. 17 subjects (42,5%) were in CA genotype (heterozigous mutant) and 23 subjects (57,5%) were in AA genotype (homozigous mutant). From 40 subjects in this study, 17 C allotype (21,25%) and 63 A allotype (78,75%) were identified. Conclusion: The frequencies of AA genotype and A allotype was found higher in epithelial ovarian carcinoma at RSMH Palembang.

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Inventory Code Barcode Call Number Location Status
1407000622T81883T818832014Central Library (Referens)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T818832014
Publisher
Palembang : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya.,
Collation
xiii, 67 hlm.; ill.; tab.; 28 cm.
Language
Indonesia
ISBN/ISSN
-
Classification
618.110 7
Content Type
Text
Media Type
unmediated
Carrier Type
unspecified
Edition
-
Subject(s)
Kanker Ovarium Epitelial
Pendidikan Dokter
Specific Detail Info
-
Statement of Responsibility
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No other version available

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