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PREPARASI DAN KARAKTERISASI SUBMIKRO PARTIKEL POLY LACTIC CO-GLYCOLIC ACID (PLGA) PEMBAWA EKSTRAK ETANOL DAUN SIRIH (Piper betle L.) DENGAN STABILIZER POLYVINYL ALCOHOL (PVA)

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Penilaian

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The ethanol extract of betel leaf has antibacterial activity, namely flavonoids which are unstable to high temperature and intensity, so a polymer-based submicroparticle suspension was made in the form of PLGA and PVA stabilizer. This study aims to determine the effect of variations in the concentration of PVA in the formulation, with flavonoids (quercetin) as the active substance. Preparation of submicro particle suspension using Emulsion Solvent Evaporation method. The study used 3 formulas with variations of PVA 40mg; 50mg, and 60mg; The optimum formula will be determined based on the highest % EE value. Formula 1, 2 and 3 have %EE respectively of 48.63%; 78.36%; 59.90%. The characterization results show the particle size value of 293.8; PDI 0.237; and zeta potential -17.63. The results of the physical stability test showed that there was a change in color to cloudy yellow, fading, there was a slight precipitate (aggregation occurred) on the 12th day, and the aroma did not change, and the pH decreased from 4.93 to 4.7 on the 12th day. Based on the data obtained, formula 2 as the optimum formula and submicro suspension has good particle characteristics but lacks physical stability.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2107004195	T58364	T583642021	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T583642021

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2021

Collation

xvii, 97 hlm,: ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.707

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Prodi Ilmu Farmasi
Farmakodinamik, Daun Sirih

Specific Detail Info

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Statement of Responsibility

MURZ

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