Skripsi

UJI TOKSISITAS TERATOGENIK EKSTRAK ETANOL DAUN KIRINYUH (CHROMOLAENA ODORATA) TERHADAP FETUS MENCIT (MUS MUSCULUS)GALUR SUB SWISS WEBSTER

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Penilaian

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Kirinyuh (Chromolaena odorata) is a plant with medicinal effect including antidiabetic, antibacterial, antispasmodik, antihypertensive, and anti-inflammatory. Previous research has done an acute toxicity test with an LD50 value of 16,501 g / KgBW. To complement the safety data, a special toxicity test was carried out, namely teratogenic toxicity at a dose of 100.250, and 500 mg / KgBW given orally during the organogenesis period, namely on the 9th to 17th day of pregnancy. On the 18th day the mother mice were operated on and the fetus removed from the uterus. The parameters observed were the number of fetuses, live fetuses, dead fetuses, implantation, resorption, fetal body weight, external abnormalities and internal abnormalities of the fetal skeleton. The results of the study concluded that the administration of ethanolic extract kirinyuh leaf at a dose of 100,250, and 500 mg / KgBW had a significant effect on the delay in the growth of the intraparietal bone and dumbbell sternum shape (Fhit> Fcrit 0.05) and had a very significant effect on the delay in reinforcing the supraoccipital bone, cervical vertebral body, and sacrokaudal vertebral body. , sternum cleaved shape, metacarpal, and metatarsal (Fhit> Fcrit 0.01). The DMRT test concluded that giving kirinyuh leaf ethanol extract caused teratogenic toxicity effects with a minimum dose of P (1) 100 mg/ KgBB.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2107003493	T51789	T517892021	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T517892021

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alamc., 2021

Collation

xvi, 95 hlm,: ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.707

Content Type

Text

Media Type

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Carrier Type

-

Edition

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Subject(s)

Prodi Ilmu Farmasi
Farmakodinamik-Ekstrak Etanol Daun Kerinyuh

Specific Detail Info

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Statement of Responsibility

MURZ

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