Skripsi

UJI AKTIVITAS ANTIBAKTERI GEL HPMC 60-SH PEMBAWA SUBMIKRO PARTIKEL ERITROMISIN TERHADAP KULIT TIKUS TERINFEKSI STAPHYLOCOCCUS AUREUS

---

Penilaian

---

A research regarding formulation and optimization of gel from erythromycin submicro particles using gelling agent HPMC 60-SH has been conducted. The concentration of HPMC 60-SH was used 2% for first formula, 4% for second formula, and 6% for third formula. Based of the observation result showed that HPMC 60-SH 2% has been produced a gel with highest quality than any other formula. The test result of viscosity, adhesibilty, spreadbility, washability, pH, and extrudability from formula using HPMC 60-SH 2% were by 1111 ± 13,75 cP; 69,23 ± 1 detik ; 5,27 ± 0,11 cm; 13,67 ± 0,005 mL; 5,35 ± 0,005; 2,42 ± 0,09 cm. Gel of HPMC 60-SH 2% showed good homogeneity and free of agglomerates. Its stability is good because the organoleptic, pH, and homogeneity remain stable during last cycle of heating cooling. The effectiveness of gel was observed through in-vivo testing with animal test infected to Staphylococcus aureus. Number of lesions on test animal skin smeared with gel from erythromycin submicro particles were lost on the 9th day, whereas in the other group of test animals smeared with optimum formula without active substances, HPMC plus 50 mg erythromycin, and without treatment still showed the presence of red lesions on the surface of test animal skin on the 9th day. Gel from erythromycin submicro particles with HPMC 60-SH 2% showed the greatest and fastest decrease of lesions when compared with other group of test animals.

---

Availability

Inventory Code	Barcode	Call Number	Location	Status
2107003491	T40338	T403382021	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

-

Call Number

T403382021

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2021

Collation

xvi, 88 hlm,: ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

-

Classification

615.407

Content Type

Text

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Prodi Ilmu Farmasi
Farmasi Praktis, Antibakteri Gel

Specific Detail Info

-

Statement of Responsibility

MURZ

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment