Skripsi

ISOLASI SENYAWA STEROID DARI TANAMAN Gynura pseudochina (Lour) DC DAN UJI AKTIVITAS ANALGETIKA TERHADAP MENCIT JANTAN (Mus musculus)

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Penilaian

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The secondary metabolites have been isolated from nonpolar fraction of methanol extract of Gynura pseudochina (Lour) DC plants. The extraction was done by maseration. Separation and purification were done by column chromatography. The isolated compound was a white solids with melting point 123 °C-125°C. The structure of this compound was determined based on spectral evidence including IR, 13C-NMR, 'H-NMR, HSQC, HMBC and COSY. The spectral data analysis were suggested that the isolated compound is a mixture of two steroids which is stigmast-5-en-3-ol or (3-sitosterol as a major compound. The analgesic activity of the isolated compound was tested in male mice by writhing test method with 1% acetic acid as the pain-inducer. The isolated compound showed that pain-inhibition activity were 56,2 % for 2 mg/20 g BB dose and 67 % for 4 mg/20 g BB dose. The analgesic activity of the isolated compound is lower thanthe aspirin. Key words: Gynura pseudochina (Lour) DC, Steroid, Stigmast-5-en-3-ol, analgesic activity.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
1307000451	T70089	T700892012	Central Library (REFERENCES)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T700892012

Publisher

Inderalaya : Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2012

Collation

xvii, 64 hlm.; ill.; tab.; 28 cm.

Language

Indonesia

ISBN/ISSN

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Classification

572.579 07

Content Type

Text

Media Type

unmediated

Carrier Type

unspecified

Edition

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Subject(s)

Jurusan Kimia
Kimia bioinorganik

Specific Detail Info

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Statement of Responsibility

Furika

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