Skripsi

UJI EFEK IMUNOMODULATOR EKSTRAK ETANOL DAUN CEMPEDAK (ARTOCARPUS INTEGER) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI SALMONELLA TYPHIMURIUM

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Penilaian

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Cempedak (Artocarpus integer) leaves contain phenolic and flavonoid compounds that have the ability to stimulate specific and nonspecific immune responses. This study aims to determine the immunomodulatory effects ethanol extract of Cempedak leaves against white rats induced Salmonella typhimurium. Immunity parameters measured were level leukocytes, lymphocytes, monocytes, neutrophils, CD4 T cells, macroscopic and histopathology of the spleen. The white rats were divided into six groups. Normal (0.5 mL/kgBW Na-CMC), positive control (Stimuno), negative control (0.5 mL/kgBW Na-CMC), and the treatment groups with a therapeutic dose 200 mg/kgBW, 400mg/kgBW, and 600 mg/kgBW. S. typhimurium was injected intraperitoneally on day 8 with a dose 0.5 mL x 105 CFU/mL in all treatment group except the normal. Total phenolic content in the ethanol extract of cempedak leaves is 331.20 ± 17.96 mgGAE/g and total flavonoid content is 82.52 ± 4.55 mgQE/g extract. The result showed ethanol extract of cempedak leaves dose 600 mg/kgBW can increased the number of T CD4, leukocytes, lymphocytes monocytes and neutrophils compared to normal group. The higher the dose given, the less severe the necrosis.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2107003786	T55257	T552572021	Central Library (REFERENCES)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T552572021

Publisher

Inderalaya : Prodi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2021

Collation

xix, 100 hlm. : ilus. ; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.707

Content Type

Text

Media Type

unmediated

Carrier Type

unspecified

Edition

-

Subject(s)

Prodi Farmasi
Farmakodinamik

Specific Detail Info

-

Statement of Responsibility

Win

Other version/related

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