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Image of PEMBUATAN ASAM-3-OKSOURSOLAT DAN ASAM-3-OKSO OLEANOLAT DARI TRITERPENOID BUAH TEMBESU SERTA AKTfVITAS SITOTOKSIK TERHADAP SEL LEUKEMIA P-388 SECARA IN-VITRO

Skripsi

PEMBUATAN ASAM-3-OKSOURSOLAT DAN ASAM-3-OKSO OLEANOLAT DARI TRITERPENOID BUAH TEMBESU SERTA AKTfVITAS SITOTOKSIK TERHADAP SEL LEUKEMIA P-388 SECARA IN-VITRO

Agustriana, Eva - Personal Name;

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Oxidation of the hydroxyl group (C-3 -OH) of ursolic acid [oleanolic acid], isolated from methanolic extract of tembesu fruit, had been done using Jones’ reagent (C1O3/H2SO4/H2O) in acetone with 40% yield. Spectrum data of ]H-NMR showed that the methine proton at C-3 position of the triterpenoids was no longer existed, and the analysis of mass spectrum showed that the oxidation products had molecular weight of 454 which was apropriate for compounds with moiecular formula C3oH46035 DBE = 8. These oxidation products, 3-oxoursolic acid [3-oxooIeanolic acid], with IC50 value of 18.5954 |ig/mL had cytotoxic activity against leukemia murine P-388 2.8 fold more active than the parent compounds, ursolic acid [oleanolic acid], with IC50 value of 53.4965 pg/mL.


Availability
Inventory Code Barcode Call Number Location Status
1407002434T66671T666712014Central Library (REFERENCES)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T666712014
Publisher
Inderalaya : Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2014
Collation
xv, 38 hlm.; ill.; tab.; 28 cm.
Language
Indonesia
ISBN/ISSN
-
Classification
541.307
Content Type
Text
Media Type
unmediated
Carrier Type
unspecified
Edition
-
Subject(s)
Jurusan Kimia
Reaksi kimia, sintesis kimia
Specific Detail Info
-
Statement of Responsibility
Furika
Other version/related

No other version available

File Attachment
  • PEMBUATAN ASAM-3-OKSOURSOLAT DAN ASAM-3-OKSO OLEANOLAT DARI TRITERPENOID BUAH TEMBESU SERTA AKTfVITAS SITOTOKSIK TERHADAP SEL LEUKEMIA P-388 SECARA IN-VITRO
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