Skripsi

PEMBUATAN ASAM-3-OKSOURSOLAT DAN ASAM-3-OKSO OLEANOLAT DARI TRITERPENOID BUAH TEMBESU SERTA AKTfVITAS SITOTOKSIK TERHADAP SEL LEUKEMIA P-388 SECARA IN-VITRO

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Penilaian

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Oxidation of the hydroxyl group (C-3 -OH) of ursolic acid [oleanolic acid], isolated from methanolic extract of tembesu fruit, had been done using Jones’ reagent (C1O3/H2SO4/H2O) in acetone with 40% yield. Spectrum data of ]H-NMR showed that the methine proton at C-3 position of the triterpenoids was no longer existed, and the analysis of mass spectrum showed that the oxidation products had molecular weight of 454 which was apropriate for compounds with moiecular formula C3oH46035 DBE = 8. These oxidation products, 3-oxoursolic acid [3-oxooIeanolic acid], with IC50 value of 18.5954 |ig/mL had cytotoxic activity against leukemia murine P-388 2.8 fold more active than the parent compounds, ursolic acid [oleanolic acid], with IC50 value of 53.4965 pg/mL.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
1407002434	T66671	T666712014	Central Library (REFERENCES)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T666712014

Publisher

Inderalaya : Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2014

Collation

xv, 38 hlm.; ill.; tab.; 28 cm.

Language

Indonesia

ISBN/ISSN

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Classification

541.307

Content Type

Text

Media Type

unmediated

Carrier Type

unspecified

Edition

-

Subject(s)

Jurusan Kimia
Reaksi kimia, sintesis kimia

Specific Detail Info

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Statement of Responsibility

Furika

Other version/related

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