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IDENTIFIKASI POLIMORFISME GEN -308 G/A TNF-α DAN KARAKTERISTIK TITER ANTIBODI PEGAWAI UNIVERSITAS SRIWIJAYA PASCAVAKSINASI SARS-COV-2 KEDUA

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Penilaian

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SARS-CoV-2 is the leading cause of world health problems today. Effective vaccines can prevent and treat a disease. The effectiveness of the vaccine can be seen from the antibody titers formed after vaccination. TNF-α is a powerful cytokine that plays a role when inflamed by antigen exposure and indirectly helps B cells to make antibodies. Polymorphism in TNF-α promoters affects the amount of TNF-α secretion, which indirectly also affects the effectiveness of a vaccine. The purpose of this research was to find out the distribution of polymorphism at the point of -308 TNF-α and the characteristic antibody titers of Sriwijaya University employees after the vaccination of the second dose of SARS-CoV-2 inactivated vaccine. This research was an observational descriptive study. The sample was taken from employees of Sriwijaya University who had carried out the second SARS-CoV-2 vaccination in the period March-August 2021. Furthermore, antibody titers examination with CMIA method and genotype examination with PCR-RFLP method. There were 25 identifiable samples. The results of the genotype research found GG genotypes as many as 18 samples (72%), AG 4 samples (16%), and AA 3 samples (12%). In the categorization of IgG antibody titers were obtained a low category of 15 samples (60%) and a high category of 10 samples (40%). In the GG genotype there were 7 samples with low category IgG titers, AG genotypes balanced between high and low categories, and genotype AA 2 people with high category IgG titers. The majority of the samples had homozygous wildtype genotype (GG) and most of the samples had low-category IgG antibody titers after the second dose of SARS-CoV-2 inactivated vaccine vaccination.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2107003526	T61738	T617382021	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T617382021

Publisher

Inderalaya : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2021

Collation

xix, 55 hlm. : ilus. ; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.920 7

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Penyakit yang Disebabkan Bakteri dan Virus
Prodi Pendidikan Dokter

Specific Detail Info

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Statement of Responsibility

SEPTA

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