Skripsi

PREPARASI DAN KARAKTERISASI SERTA UJI STABILITAS SUBMIKRO PARTIKEL POLY-(LACTIC-CO-GLYCOLIC ACID) PEMBAWA EKSTRAK ETANOL BIJI KOPI ROBUSTA (COFFEA CANEPHORA. L)

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Penilaian

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One of the biodiversity that has the potential to processed into medicinal ingredients are robusta coffee beans. Robusta coffee beans have antioxidant activity because it contains various polyphenol compounds, one of its polyphenols is chlorogenic acid. However, secondary metabolites that extracted from plants tend to be unstable in the preparation especially during storage. Therefore, robusta coffee bean extract preparation was carried out using PLGA polymer and PVA stabilizer. This research aims to improve the stability of secondary metabolites in the preparation. Submicro particle suspension was made contains of robusta coffee bean from ethanol extraction, PLGA and PVA, using variations in the concentration of PVA stabilizers of 50 mg, 100 mg, and 150 mg. The best submicro particel formulation of robusta coffee bean extract was obtained at concentration of PVA stabilizer of 50 mg, with percent encapsulation efficiency of 91.443%. The results of the stability test from submicro particle robusta coffee bean extract using the heating cooling cycle method with various buffer pH 2; 5.5; and 7.4 caused decrease of polyphenols content up to 33.752%, 23.371%, 16.848% respectively. The results of submicro particle characterization resulted in a particle diameter of 187.16 nm, poly dispersity index of 0.217 and zeta potential of -12.3 mV. Measurement of antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method resulted in the IC50 value of vitamin C compounds, robusta coffee bean ethanol extract, submicro particles of PLGA carrying robusta coffee ethanol extract before the stability test and after the stability test sequent values are 9.21 μg / mL; 61.91 μg / mL; 145.35 μg / mL; 209.02 μg / mL.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2107003473	T51780	T517802021	Central Library (REFERENCES)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T517802021

Publisher

Inderalaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2021

Collation

xviii, 117 hlm. : ilus. ; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.707

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Prodi Ilmu Farmasi
Ekstrak Etanol Biji Kopi Robusta

Specific Detail Info

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Statement of Responsibility

DS

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