Skripsi

GAMBARAN POLIMORFISME TITIK -308 PROMOTER GEN TNF-Α DAN KADAR ANTIBODI PASCA PEMBERIAN VAKSIN INAKTIF COVID-19 DOSIS KEDUA

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Penilaian

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COVID-19 vaccination is a COVID-19 long-term prevention and control strategies which currently done by the government. COVID-19 vaccination is useful for inducing significantly neutralizing antibody levels and triggering a memory response to SARS-CoV-2. The effectiveness of vaccination is influenced by various factors, one of which is genetics. Previous studies have reported the association of -308 TNF-α gene promoter polymorphism with increased production of TNF-α as a central mediator of immune response. This study aimed to describe the -308 TNF-α gene promoter polymorphism and antibody concentration post second dose COVID-19 vaccination with inactivated vaccine. This research is an observational descriptive study using PCR-RFLP method and primary data collection of IgG s1 RBD SARS-CoV-2 concentration. The sample was Palembang citizen from several institutions who had been vaccinated with the second dose of inactivated COVID-19 vaccine on March – August 2021. Data analysis was carried out using SPSS 25 to assess the frequency distribution of genotype and allele at -308 TNF-α gene promoter and antibody concentration. The results showed a total of 55 samples were identified. Most subjects were 17-25 years old (43.6%) and female (52.7%). From the PCR-RFLP results, the genotype frequency distribution of GG 85.5%, GA 12.7%, and AA 1.8%. The G allele was found in 91.8% and the A allele was 8.2%. Meanwhile, data on antibody concentration using CMIA method showed 43.6% had high antibody concentration and 56.4% had low antibody concentration.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2107003730	T60274	T602742021	Central Library (REFERENCES)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T602742021

Publisher

Palembang : Prodi Kedokteran, Fakultas Kedokteran., 2021

Collation

xvii, 72 hlm.; tab.; ilus.; 28 cm.

Language

Indonesia

ISBN/ISSN

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Classification

571.960 7

Content Type

Text

Media Type

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Carrier Type

-

Edition

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Subject(s)

Pendidikan Dokter
Vaksin Inaktif

Specific Detail Info

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Statement of Responsibility

MI

Other version/related

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