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ANALISIS HUBUNGAN SARS-COV-2 RT-PCR CYCLE THRESHOLD VALUE DENGAN MORTALITAS PADA PASIEN COVID-19 RAWAT INAP RSUP DR. MOHAMMMAD HOESIN PALEMBANG

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Penilaian

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Covid-19 has caused major public health problems that are increasing and have claimed many lives. The clinical spectrum of patients varies from mild to severe, with acute respiratory failure requiring intensive hospitalization. Research has shown an association of severe clinical outcomes with higher patient viral loads. Currently, RT-PCR, the gold standard for diagnosing Covid-19, is expected to help identify patients at risk for adverse clinical outcomes. This study was conducted to determine the relationship between CT Value and the incidence of mortality in Covid-19 patients. This study used a cross-sectional observational analysis on Covid-19 patients hospitalized from January 1 to June 30, 2021, at RSUP dr. Mohammad Hoesin Palembang. All variables are seen through the patient's medical record data at the hospital. This study correlated CT values and patient mortality by adjusting for covariate variables, such as age, gender, comorbidities, and patient severity. A total of 280 data on Covid-19 patients were used as research subjects. In the distribution of data regarding the characteristics of Covid-19 patients, from 280 samples, it was found that the majority were aged 60 years, with a median age of 51.50 patients (19-88). There are more female patients than male patients. The most common comorbid diseases in patients are hypertension and DM. In this study, the categories of other comorbid diseases were tuberculosis (TB), chronic kidney disease (CKD), acute kidney infection (AKI), malignancy (cancer), asthma, and HIV. There were more living patients than dead patients. Patients who entered nonsevere clinical conditions are more than severe patients. The highest CT Value quartile is Q1, with the median CT Value being 29.84 (11.56-39.09). Of the 54 patients, the age group with the most patients dying was at the age of 60 years, with the mean age being 57.50±17.696. The incidence of mortality was more in the male group than in the female group. Hypertension and CVD are the most common comorbidities in patients who die. Mortality events were more c ommonly found in patients admitted with severe clinical severity than nonsevere patients. The results of the analysis of the relationship between age, comorbid disease, and clinical severity with the incidence of mortality using the chisquare hypothesis t resulted in a pest value = 0.050. Meanwhile, the analysis results of the relationship between sex and the incidence of mortality resulted in p = > 0.05. That shows there is no statistically significant relationship between gender and patient mortality. Me anwhile, age, comorbid disease, and clinical severity are statistically associated with patient mortality. Patients with comorbidities have a mortality ratio of 4,043 times greater than patients who do not have comorbidities. Meanwhile, patients with sever e clinical severity had a mortality ratio of 6.573 times greater than that of nonsevere patients. The results of the analysis of the relationship between CT Value and Mortality Incidence using the chisquare hypothesis test with a 95% confidence level resu lted in a pvalue of 0.128. That shows no statistically significant relationship between CT Value and Mortality Events. The multivariate analysis of the incidence of mortality showed that patients with comorbidities had a 4,860 greater influence on patient mortality and severe clinical severity had a 17,529 greater influence on patient mortality. Meanwhile, other variables did not have a significant effect on patient mortality.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
T602922021	T60292	T602922021	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T602922021

Publisher

Indralaya : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2021

Collation

xviii, 65 hlm. : ilus. ; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.920 7

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Prodi Pendidikan Dokter
Penyakit yang di Sebabkan Bakteri dan Virus

Specific Detail Info

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Statement of Responsibility

SEPTA

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